Figure 2 | Scientific Reports

Figure 2

From: Structure–activity relationships for the G-quadruplex-targeting experimental drug QN-302 and two analogues probed with comparative transcriptome profiling and molecular modeling

Figure 2

Volcano plots of Total numbers of differentially expressed genes induced by drug dosage in MIA-PaCa2 cells for the three G4-binding compounds (CM03, SOP1247 and QN-302) at two different time points (6 h and 24 h), from RNA-seq analyses. The differentially expressed genes were sorted into 4 subgroups based on the log2 fold change (log2FC) and false discovery rate (FDR): Down (Log2 FC ≤  − 0.5, FDR ≤ 0.1), Up (Log2 FC ≥ 0.5, FDR ≤ 0.1), Down strong (Log2 FC ≤  − 1.0, FDR ≤ 0.05) and Up strong (Log2 FC ≥ 1.0, FDR ≤ 0.05). The horizontal dotted lines indicate FDR cut-offs and the vertical dotted lines indicate Log2 FC cut-offs for (left) down-regulated and (right) up-regulated genes. The numbers on the plot indicate the number of DEGs that meet the cut-offs.

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