Figure 3 | Scientific Reports

Figure 3

From: Structure–activity relationships for the G-quadruplex-targeting experimental drug QN-302 and two analogues probed with comparative transcriptome profiling and molecular modeling

Figure 3

Heat-map showing the nine clusters of differentially regulated genes in MIA-PaCa2 and PANC-1 cell lines following drug treatment. Dark-blue strips indicate the most down-regulated genes and bright red those that are the most up-regulated, in terms of log2FC values. Genes in cluster one are solely down regulated by QN-302 treatment (see also the sub-set enclosed in the box, which are detailed in Table 3). The right-hand column indicates the status of genes in a small cohort of poorly differentiated human PDAC tumour tissues, as previously reported44. The moderate correspondence with the QN-302 gene cluster is likely to reflect the small PDAC tumour sample size.

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