Table 4 Log2FC values for genes in the Hedgehog pathway down regulated by QN-302, for 24 h exposure, together with numbers of Putative G-quadruplex Sequences (PQS), from Ref.42. CM03-R is the gemcitabine-resistant MIA-PaCa2 and CM03-PANC is the PANC-1 cell line.

From: Structure–activity relationships for the G-quadruplex-targeting experimental drug QN-302 and two analogues probed with comparative transcriptome profiling and molecular modeling

Gene

QN-302 in MIA-PaCa2

SOP1247 in MIA-PaCa2

CM03 in MIA-PaCa2

CM03 in MIA-PaCa2-GemR

CM03 in PANC-1

PQS

KIF7

 − 0.62

 − 1.46

 − 1.32

 − 1.34

 − 0.67

13

SMO

 − 0.86

 − 1.42

 − 1.21

 − 0.33*

 − 0.82

12

SUFU

 − 0.22

 − 0.16

 − 0.26

 − 0.14*

0.12*

20

GLI1

 − 1.86

 − 0.13

 − 0.64

 − 0.59*

 − 0.57

15

  1. All P values are < 0.05, apart from those marked*.
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