Figure 9
From: A pivotal role for the IL-1β and the inflammasome in preterm labor
Schematic representation of putative interactions between myometrial smooth muscle cells and macrophages. This representation was a synthesis of the data presented in this article and previous publications from our team: Hadi et al.12 and Wendremaire et al.13. LPS treatment of myometrial and macrophages co-culture leads to the production by macrophages of ROS which contributed to inflammasome activation and IL-1β processing. Myometrial cytoskeleton reorganization and synchronization is directly achieved by IL-1β and ROS.
