Table 1 SSTR2a expression and correlation with clinicopathologic factors of rectal neuroendocrine tumors.

From: Somatostatin receptor 2 (SSTR2) expression is associated with better clinical outcome and prognosis in rectal neuroendocrine tumors

Clinicopathologic factors

N (%)

SSTR2 expression

Absent (%)

Present (%)

p value

Age (years)

0.325

 ≤ 50

200 (57.1)

62 (31.0)

138 (69.0)

 

 > 50

150 (42.8)

54 (36.0)

96 (64.0)

 

Sex

0.645

 Male

187 (53.4)

64 (34.2)

123 (65.8)

 

 Female

163 (46.6)

52 (31.9)

111 (68.1)

 

Grade

0.868

 G1

324 (92.6)

107 (33.0)

217 (67.0)

 

 G2

26 (7.4)

9 (34.6)

17 (65.4)

 

Size

0.001*

 ≤ 1 cm

316 (90.3)

96 (30.4)

220 (69.6)

 

 > 1 cm

34 (9.7)

20 (58.8)

14 (41.2)

 

Proper muscle invasion (n = 7)a

0.809

 Absent

4 (57.1)

3 (75.0)

1 (25.0)

 

 Present

3 (42.9)

2 (66.7)

1 (33.3)

 

Lymphovascular invasion

0.306

 Absent

342 (97.7)

112 (32.7)

230 (67.3)

 

 Present

8 (2.3)

4 (50.0)

4 (50.0)

 

Perineural invasion

0.074

 Absent

346 (98.9)

113 (32.7)

233 (67.3)

 

 Present

4 (1.1)

3 (75.0)

1 (25.0)

 

Lymph node metastasis (n = 7)a

0.147

 Absent

4 (57.1)

2 (50.0)

2 (50.0)

 

 Present

3 (42.9)

3 (100.0)

0 (0.0)

 

Distant metastasis

   

0.155

 Absent

349 (99.7)

115 (33.0)

234 (67.0)

 

 Present

1 (0.3)

1 (100.0)

0 (0.0)

 

pT classification

0.030*

 pT1

341 (97.4)

110 (32.3)

231 (67.7)

 

 pT2-4

9 (2.6)

6 (66.7)

3 (33.3)

 

AJCC stage group

0.012*

 I

338 (96.6)

108 (32.0)

230 (68.0)

 

 II–IV

12 (3.4)

8 (66.7)

4 (33.3)

 

Chromogranin expression

0.009*

 Absent

289 (82.6)

87 (30.1)

202 (69.9)

 

 Present

61 (17.4)

29 (47.5)

32 (52.5)

 

Somatostatin expression

0.070

 Absent

324 (92.6)

105 (32.4)

219 (67.6)

 

 Present

19 (5.4)

10 (52.6)

9 (47.4)

 
  1. SSTR somatostatin receptor, AJCC American Joint Committee on Cancer.
  2. *Statistically significant at p < 0.05.
  3. aCases of endodscopically resected neuroendocrine tumors were not applicable for proper muscle invasion and lymph node metastasis and were excluded from this analysis.
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