Table 2 Univariate and multivariate analyses.

From: Somatostatin receptor 2 (SSTR2) expression is associated with better clinical outcome and prognosis in rectal neuroendocrine tumors

Clinicopathologic factors

5YSR (%)

Univariate analysis

Multivariate analysis

HR

95% CI

p value

HR

95% CI

p value

Age (years)

0.054

   

 ≤ 50

96.6

1.00

     

 > 50

96.9

2.167

0.967–4.856

    

Sex

0.784

   

 Male

98.0

1.00

     

 Female

95.4

1.116

0.507–2.456

    

Grade

0.001*

  

0.002*

 NET G1

96.9

1.00

  

1.00

  

 NET G2

95.2

5.719

1.793–18.243

 

6.633

2.023–21.746

 

Size

0.685

   

 ≤ 1 cm

96.8

1.00

     

 > 1 cm

96.2

1.354

0.311–5.889

    

Proper muscle invasion

0.232

   

 Absent or NAa

96.7

1.00

     

 Present

75.0

3.210

0.424–24.296

    

Lymphovascular invasion

0.029*

  

0.492

 Absent

97.0

1.00

  

1.00

  

 Present

87.5

4.455

1.027–19.317

 

1.789

0.341–9.390

 

Perineural invasion

0.668

   

 Absent

96.7

1.00

     

 Present

#

      

Lymph node metastasis

0.041*

  

0.633

 Absent or NAa

96.7

1.00

  

1.00

  

 Present

50.0

6.371

0.826–49.136

 

0.542

0.044–6.702

 

Distant metastasis

 < 0.001*

  

 < 0.001*

 Absent

97.1

1.00

  

1.00

  

 Present

0

72.812

8.132–651.909

 

58.519

6.116–559.950

 

pT classification

0.388

   

 pT1

96.6

1.00

     

 pT2–4

80.0

2.374

0.314–17.942

    

AJCC stage group

0.058

   

 I

97.0

1.00

     

 II–IV

90.9

3.775

0.862–16.537

    

Chromogranin expression

0.900

   

 Absent

96.0

1.00

     

 Present

96.3

0.934

0.320–2.726

    

SSTR2 expression

0.006*

  

0.014*

 Absent

92.6

1.00

  

1.00

  

 Present

98.5

0.346

0.157–0.759

 

0.365

0.164–0.815

 
  1. *Statistically significant at p < 0.05.
  2. aEndoscopically resected neuroendocrine tumors were regarded as not applicable cases.
  3. #All cases are censored so statistics are not calculated.
  4. SSTR somatostatin receptor, NA not applicable, AJCC American Joint Committee on Cancer, HR hazard ratio, CI confidence interval.
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