Table 3 Summary of hematological changes after dosing CeO2 NPs for 90 days. Data are represented as mean ± SD.

From: Safety assessment and gastrointestinal retention of orally administered cerium oxide nanoparticles in rats

 

Unit

Male

Female

Control

10 mg/kg/day

100 mg/kg/day

1000 mg/kg/day

Control

10 mg/kg/day

100 mg/kg/day

1000 mg/kg/day

RBC

(× 10^6/µL)

8.82 ± 0.405

8.80- ± 0.389

8.89 ± 0.475

8.83 ± 0.521

8.23 ± 0.223

8.07 ± 0.459

8.09 ± 0.363

8.23 ± 0.369

HGB

(g/dL)

15.2 ± 0.94

15.4 ± 0.75

15.6 ± 0.58

15.2 ± 0.49

15.1 ± 0.36

15.0 ± 0.50

15.1 ± 0.80

15.4 ± 0.60

HCT

(%)

50.0 ± 2.98

50.3 ± 2.54

51.1 ± 1.97

49.7 ± 1.74

48.4 ± 1.09

48.2 ± 2.11

48.8 ± 2.81

48.7 ± 1.88

MCV

(fL)

56.6 ± 1.82

57.1 ± 1.37

57.6 ± 2.64

56.4 ± 1.94

58.8 ± 0.96

59.8 ± 1.83

60.4 ± 1.80

59.2 ± 1.75

MCH

(pg)

17.3 ± 0.62

17.4 ± 0.48

17.6 ± 0.91

17.2 ± 0.69

18.3 ± 0.46

18.5 ± 0.63

18.7 ± 0.44

18.7 ± 0.47

MCHC

(g/dL)

30.5 ± 0.28

30.6 ± 0.50

30.5 ± 0.36

30.5 ± 0.50

31.2 ± 0.36

31.1 ± 0.45

31.0 ± 0.43

31.6 ± 0.48

RET

(%)

2.14 ± 0.211

2.03 ± 0.277

1.93 ± 0.254

1.79 ± 0.299*

1.96 ± 0.314

2.05 ± 0.284

1.97 ± 0.266

1.92 ± 0.284

RETA

(10^9/L)

189 ± 21.1

178 ± 26.5

171 ± 19.9

158 ± 25.6*

162 ± 28.9

165 ± 20.7

159 ± 19.5

158 ± 22.5

PLT

(103/µL)

1169.2 ± 219.81

1148.9 ± 90.70

1009.6 ± 302.83

1163.0 ± 131.78

1081.8 ± 130.16

1090.6 ± 184.16

1059.2 ± 84.91

1131.6 ± 70.55

NEU

(%)

16.1 ± 5.17

14.6 ± 35.4

15.1 ± 4.64

14.7 ± 4.81

15.2 ± 6.05

11.7 ± 3.79

12.5 ± 5.25

12.5 ± 3.75

LYM

(%)

77.5 ± 5.72

79.5 ± 3.91

79.2 ± 4.31

79.7 ± 5.82

79.5 ± 5.44

82.4 ± 4.78

81.7 ± 5.65

81.7 ± 3.96

EOS

(%)

1.5 ± 0.41

1.5 ± 0.39

1.1 ± 0.31

1.2 ± 0.54

1.4 ± 0.40

1.6 ± 0.24

1.5 ± 0.45

1.5 ± 0.51

MON

(%)

3.8 ± 1.20

3.8 ± 1.04

3.6 ± 0.77

3.3 ± 1.22

2.9 ± 0.82

3.2 ± 1.30

2.8 ± 0.66

3.0 ± 1.27

BAS

(%)

0.5 ± 0.12

0.4 ± 0.10

0.4 ± 0.13

0.4 ± 0.12

0.5 ± 0.17

0.5 ± 0.18

0.6 ± 0.23

0.5 ± 0.19

LUC

(%)

0.7 ± 0.26

0.6 ± 0.12

0.6 ± 0.22

0.7 ± 0.21

0.6 ± 0.39

0.7 ± 0.20

0.9 ± 0.40

0.8 ± 0.36

WBC

(× 103/µL)

12.34 ± 4.137

11.77 ± 2.656

9.75 ± 2.241

10.10 ± 1.910

7.43 ± 2.068

6.74 ± 1.511

7.25 ± 2.257

7.13 ± 1.437

  1. * Significant differences from control group (p < 0.05).
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