Table 5 Absolute organ weights after CeO₂ NPs treatment at 10, 100 and 1000 mg/kg/day for 90 days. Data are represented as mean ± SD.

Adrenal glands

0.068 ± 0.0086

0.067 ± 0.0090

0.061 ± 0.0102

0.066 ± 0.0099

0.084 ± 0.0145

0.079 ± 0.0126

0.085 ± 0.0155

0.080 ± 0.0183

Brain

2.172 ± 0.0763

2.230 ± 0.1016

2.188 ± 0.1323

2.211 ± 0.0950

2.037 ± 0.0849

2.082 ± 0.1197

2.107 ± 0.1315

2.033 ± 0.0183

Heart

1.712 ± 0.1212

1.803 ± 0.1573

1.669 ± 0.1876

1.658 ± 0.1237

1.097 ± 0.0903

1.087 ± 0.1568

1.091 ± 0.1032

2.033 ± 0.0840

Kidneys

4.053 ± 0.5126

4.131 ± 0.4541

3.975 ± 0.4439

4.070 ± 0.2951

2.203 ± 0.2132

2.197 ± 0.2559

2.398 ± 0.3362

2.330 ± 0.2374

Liver

16.860 ± 3.0411

16.352 ± 1.7828

15.398 ± 2.1129

15.682 ± 1.6165

8.745 ± 0.8305

8.450 ± 0.8574

9.360 ± 1.2754

8.804 ± 0.6821

Spleen

0.995 ± 0.0871

1.048 ± 0.1229

0.867 ± 0.1573

0.924 ± 0.1491

0.603 ± 0.1009

0.565 ± 0.0737

0.641 ± 0.0626

0.590 ± 0.0756

Thymus

0.439 ± 0.0850

0.431 ± 0.0908

0.350 ± 0.0488

0.411 ± 0.0930

0.295 ± 0.0598

0.322 ± 0.0701

0.353 ± 0.0383

0.344 ± 0.0317

Thyroid and parathyroid glands

0.028 ± 0.0036

0.032 ± 0.0065

0.029 ± 0.0052

0.029 ± 0.0066

0.022 ± 0.0044

0.026 ± 0.0050

0.026 ± 0.0070

0.023 ± 0.0039

Lung

1.873 ± 0.1433

2.039 ± 0.2642

1.812 ± 0.1711

1.815 ± 0.1357

1.380 ± 0.1020

1.402 ± 0.1667

1.409 ± 0.1557

1.394 ± 0.1856

Testes

3.523 ± 0.2563

3.670 ± 0.2802

3.642 ± 0.2084

3.591 ± 0.2354

–

–

–

–

Ovaries

–

–

–

–

0.098 ± 0.0144

0.104 ± 0.0215

0.102 ± 0.0309

0.110 ± 0.0193

Uterus/cervix

–

–

–

–

0.784 ± 0.1917

0.791 ± 0.2525

0.797 ± 0.2056

0.696 ± 0.1631