Table 7 Summary of microscopic findings at control and 1000 mg/kg/day-dosed rat for 90 days.
Males | Females | ||||
|---|---|---|---|---|---|
Control | 1000 mg/kg | Control | 1000 mg/kg | ||
Adrenal glands | Vacuolation, zona fasciculata | 2(1 >) | 1(1 >) | ||
Heart | Cardiomyopathy | 2(1 >) | 0(1 >) | ||
Infiltration, mononuclear cell | 0(1 >) | 1(1 >) | 1(1 >) | 0(1 >) | |
Kidneys | Basophilia, tubules | 4(1 >) | 1(1 >) | ||
Cyst(s) | 2(1 >) | 1(1 >) | |||
Dilation, pelvis | 1(1 >) | 0(1 >) | |||
Infiltration, mononuclear cell | 3(1 >) | 2(1 >) | |||
Nephropathy, focal | 0(1 >) | 1(1 >) | |||
Mineralization | 1(1 >) | 0(1 >) | |||
Liver | Infiltration, mononuclear cell | 4(1 >) | 4(1 >) | 1(1 >) | 1(1 >) |
Lung with bronchi | Alveolar macrophage aggregation | 1(1 >) | 1(1 >) | 1(1 >) | 1(1 >) |
Infiltration, eosinophil, perivascular | 1(1 >) | 0(1 >) | |||
Pleural fibosis | 1(1 >) | 0(1 >) | |||
Infiltration, mononuclear cell | 0(1 >) | 2(1 >) | |||
Pigmented macrophages | 0(1 >) | 2(1 >) | |||
Pancreas | Atrophy, acinar cell | 2(1 >) | 3(1 >) | ||
Infiltration, mononuclear cell | 1(1 >) | 1(1 >) | |||
Prostate | Infiltration, mononuclear cell | 2(1 >) | 6(1 >) | ||
Skin | Congestion/hemorrhage | 1(2 >) | 0(2 >) | ||
Erosion/ulcer | 1(2 >) | 0(2 >) | |||
Granulomatous inflammation | 1(3 >) | 0(3 >) | |||
Skin, inguinal | Erosion | 1(1 >) | 0(1 >) | ||
Testes | Atrophy, tubular | 1(1 >) | 0(1 >) | ||
