Figure 1
From: Inflammation drives pathogenesis of early intestinal failure-associated liver disease
Parenteral nutrition in preterm piglets results in histologic and biochemical cholestasis by day of life 15. Representative hematoxylin & eosin-stained liver tissue is shown from a bottle-fed piglet (a) and a PN piglet (b). Piglets receiving PN demonstrate extensive bile deposition (arrows) and steatosis (asterisk), while the bottle-fed piglets have mild bile pigment predominantly noted within Kupfer cells (arrows), with rare steatosis. Piglets in the PN group developed biochemical cholestasis marked by increased plasma total bilirubin (c), direct bilirubin (d), and gamma glutamyl transferase (e) at day of life 15. Mean ± SEM. Comparisons with Welch’s t-test with Holm-Sidak correction for multiple testing. *P < 0.05.
