Table 1 Top 20 predicted activated and inhibited upstream regulators in Ingenuity Pathway Analysis.
From: Inflammation drives pathogenesis of early intestinal failure-associated liver disease
Upstream regulator | Expr log ratio | Molecule type | Activation z-score | p-value of overlap | # genes in network | # regulators in network |
|---|---|---|---|---|---|---|
TNF | Cytokine | 5.247 | 4.74E−34 | 235 | 13 | |
IL1B | Cytokine | 5.197 | 1.87E−21 | 233 | 14 | |
IFNG | Cytokine | 5.116 | 1.71E−17 | 233 | 15 | |
IL1A | Cytokine | 4.918 | 5.42E−16 | 219 | 16 | |
KLF6 | 1.063 | Transcription regulator | 4.697 | 1.31E−12 | 179 | 17 |
NFkB (complex) | Complex | 4.357 | 4.17E−24 | 254 | 15 | |
CDKN2A | Transcription regulator | 4.316 | 3.01E−11 | 251 | 23 | |
TLR7 | Transmembrane receptor | 4.042 | 1.63E−07 | 219 | 17 | |
RELA | 0.372 | Transcription regulator | 3.722 | 3.63E−12 | 261 | 15 |
Interferon alpha | Group | 3.487 | 1.85E−11 | 176 | 15 | |
SMARCB1 | 0.068 | Transcription regulator | 3.487 | 1.44E−07 | 222 | 18 |
ZFTA-RELA | Fusion gene/product | 3.464 | 8.16E−09 | |||
BHLHE40 | -0.027 | Transcription regulator | 3.453 | 7.06E−07 | 191 | 12 |
CD40LG | 0.018 | Cytokine | 3.447 | 4.85E−12 | 230 | 14 |
LDL | Complex | 3.404 | 4.42E−06 | 281 | 20 | |
IL27 | 0.617 | Cytokine | 3.368 | 3.9E−09 | 253 | 17 |
CSF2 | Cytokine | 3.367 | 1.39E−12 | 238 | 14 | |
CD40 | 1.287 | Transmembrane receptor | 3.336 | 3.35E−07 | 211 | 13 |
ZBTB10 | 0.309 | Transcription regulator | 3.317 | 0.00506 | 109 | 7 |
TICAM1 | 0.211 | Other | 3.303 | 1.14E−05 | 197 | 20 |
E2F1 | − 1.819 | Transcription regulator | − 4.415 | 4.48E−12 | 162 | 15 |
E2f | Group | − 3.925 | 2.41E−13 | 142 | 9 | |
CD3E | − 0.188 | Transmembrane receptor | − 3.873 | 1.06E−12 | 224 | 19 |
CITED2 | − 0.162 | Transcription regulator | − 3.786 | 9.99E−06 | 196 | 14 |
TREX1 | 0.541 | Enzyme | − 3.721 | 1.03E−09 | 145 | 12 |
ACOX1 | − 0.034 | Enzyme | − 3.441 | 1.09E−08 | 176 | 7 |
IL1RN | Cytokine | − 3.373 | 1.36E−09 | 237 | 17 | |
RNASEH2B | 0.045 | Other | − 3.357 | 1.05E−07 | ||
Ttc39aos1 | Other | − 3.284 | 2.48E−06 | 128 | 7 | |
Eldr | Other | − 3.162 | 5.85E−06 | |||
GFI1 | 2.419 | Transcription regulator | − 3.162 | 0.00127 | 211 | 13 |
ZBTB20 | − 0.426 | Transcription regulator | − 3.148 | 2.94E−06 | 136 | 7 |
SP110 | 0.31 | Transcription regulator | − 3.051 | 0.00031 | ||
ABCB4 | Transporter | − 2.996 | 2.23E−08 | 118 | 7 | |
EP400 | 0.358 | Other | − 2.985 | 4.47E−08 | ||
TARDBP | 0.083 | Transcription regulator | − 2.764 | 4.57E−05 | ||
E2F3 | 0.137 | Transcription regulator | − 2.72 | 2.71E−09 | 164 | 16 |
miR-199a-5p | Mature microrna | − 2.714 | 2.9E−06 | |||
SSTR2 | G-protein coupled receptor | − 2.714 | 1.6E−08 | 251 | 23 | |
TNFRSF9 | 3.908 | Transmembrane receptor | − 2.692 | 3.69E−12 | 171 | 15 |
