Table 2 Top 20 biologic and chemical drugs identified as inhibited master regulators by causal network analysis in ingenuity pathway analysis.

Dienogest

Chemical drug

− 5.488

8.26E−28

202

40

Paricalcitol

Chemical drug

− 4.911

4.25E−28

209

51

Infliximab

Biologic drug

− 4.667

1.21E−32

144

3

SC-58125

Chemical drug

− 4.469

3.66E−32

146

4

Bosentan

Chemical drug

− 4.216

2.39E−30

90

9

CGP53716

Chemical drug

− 4.041

2.61E−29

75

2

Dicumarol

Chemical drug

− 4.025

1.18E−25

80

4

Erythromycin

Chemical drug

− 3.976

2.52E−24

82

8

Ambroxol

Chemical drug

− 3.75

2.49E−24

64

4

Obeticholic acid

Chemical drug

− 3.671

6.42E−28

76

4

Glycyrrhizic acid

Chemical drug

− 3.624

4.22E−26

88

10

Trimetazidine

Chemical drug

− 3.578

1.43E−25

80

7

IKK-2 inhibitor VIII

Chemical drug

− 3.464

1.9E−37

192

33

Methylprednisolone succinate

Chemical drug

− 3.41

4.31E−29

159

26

Betamethasone valerate

Chemical drug

− 3.41

4.31E−29

159

26

Milrinone

Chemical drug

− 3.394

2.32E−24

73

5

Rottlerin

Chemical drug

− 3.359

1.22E−27

149

25

KPT-9274

Chemical drug

− 3.359

7.94E−32

149

21

Acamprosate

Chemical drug

− 3.302

1.02E−30

106

12

Damnacanthal

Chemical drug

− 3.273

5.5E−27

84

4