Figure 2

Bimodality results from a combination of a steep dose–response relationship and cell-to-cell variability. (a) Experimental dose–response curves of pCD79a, pSYK and pPLCγ2 (t = 10 min). (b) Normalised experimental dose–response curves with \({{\text{EC}}}_{50}\) (point) and estimated bimodality range (shaded area; proxy for cell-to-cell variability). (c) Minimal model of the BCR network. (d) Simulated dose–response curves of pCD79a, pSYK and pPLCγ2.