Table 1 Baseline characteristics of the pre-matched and matched cohorts.

From: Sex differences in in-hospital management in patients with sepsis and septic shock: a prospective multicenter observational study

 

Before matching

After matching

Women (n = 1357)

Men (n = 1772)

Standardized difference

Women (n = 1190)

Men (n = 1190)

Standardized difference

Age (years)

72.0 [62.0–80.0]

70.0 [61.5–78.0]

0.112

71.0 [62.0–80.0]

70.0 [62.0–78.0]

0.037

Septic shock

791 (58.3%)

1085 (61.2%)

0.060

706 (59.3%)

721 (60.6%)

0.026

SOFA score

8 [6–11]

9 [7–12]

0.173

8 [6–11]

9 [7–11]

0.083

APACHE II score

21 [15–27]

21 [16–28]

0.102

21 [15–27]

21 [16–28]

0.050

Initial vital signs

 SBP (mmHg)

90.0 [75.0–112.0]

92.0 [78.0–114.0]

0.048

90.0 [75.0–113.0]

92.0 [78.0–115.0]

0.061

 DBP (mmHg)

54.0 [46.0–67.0]

56.0 [48.0–68.0]

0.082

54.0 [46.0–67.0]

56.0 [48.0–68.0]

0.075

 HR (1/min)

109.0 [92.0–126.0]

111.0 [95.0–128.0]

0.085

110.0 [92.0–127.0]

110.0 [94.0–127.0]

0.030

 RR (1/min)

20.0 [18.0–24.0]

20.0 [18.0–24.0]

0.065

20.0 [18.0–24.0]

20.0 [18.0–24.0]

0.005

 BT (℃)

37.7 [36.7–38.8]

37.6 [36.6–38.6]

0.102

37.7 [36.7–38.7]

37.7 [36.7–38.7]

0.006

Infection focus

 Respiratory

207 (15.3%)

529 (29.9%)

0.355

207 (17.4%)

217 (18.2%)

0.022

 Genitourinary

384 (28.3%)

185 (10.4%)

0.464

217 (18.2%)

184 (15.5%)

0.074

 Gastrointestinal

169 (12.5%)

201 (11.3%)

0.034

169 (14.2%)

156 (13.1%)

0.032

 Hepatobiliary

204 (15.0%)

365 (20.6%)

0.146

204 (17.1%)

219 (18.4%)

0.033

 Mixed

233 (17.2%)

280 (15.8%)

0.037

233 (19.6%)

236 (19.8%)

0.006

 Others

160 (11.8%)

212 (12.0%)

0.005

160 (13.4%)

178 (15.0%)

0.043

Comorbidities

 HTN

631 (46.5%)

711 (40.1%)

0.129

549 (46.1%)

521 (43.8%)

0.047

 DM

427 (31.5%)

597 (33.7%)

0.047

360 (30.3%)

409 (34.4%)

0.088

 Cardiac disease

173 (12.7%)

305 (17.2%)

0.125

161 (13.5%)

161 (13.5%)

0.001

 Chronic lung disease

57 (4.2%)

196 (11.1%)

0.261

57 (4.8%)

61 (5.1%)

0.015

 Hematologic malignancy

103 (7.6%)

157 (8.9%)

0.046

98 (8.2%)

104 (8.7%)

0.018

 Metastatic cancer

403 (29.7%)

605 (34.1%)

0.095

367 (30.8%)

416 (35.0%)

0.088

 Chronic renal disease

123 (9.1%)

168 (9.5%)

0.014

113 (9.5%)

113 (9.5%)

0.001

 Chronic liver disease

100 (7.4%)

204 (11.5%)

0.142

97 (8.2%)

97 (8.2%)

0.001

Laboratory data

 Lactate (initial) (mmol/L)

3.2 [1.9–5.5]

3.9 [2.2–5.9]

0.117

3.2 [2.0–5.6]

3.7 [2.1–5.7]

0.041

 WBC (× 103/μL)

10.0 [4.1–17.0]

10.0 [3.9–16.6]

0.035

9.7 [3.9–17.0]

10.0 [3.9–16.2]

0.041

 CRP (mg/dL)

14.5 [6.2–25.0]

14.7 [6.4–24.6]

0.014

14.5 [6.2–25.3]

14.8 [6.5–24.6]

0.005

  1. Data are expressed as median [interquartile range], mean ± standard deviation, or frequency (proportion), as appropriate.
  2. SOFA Sequential Organ Failure Assessment, APACHE Acute Physiologic Assessment and Chronic Health Evaluation, SBP systolic blood pressure, DBP diastolic blood pressure, HR heart rate, RR respiratory rate, BT body temperature, HTN hypertension, DM diabetes mellitus, WBC white blood cell, CRP C-reactive protein.
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