Table 2 Vascular and neurovascular inflammation from normal-to-hyperintense white matter.

From: Three-dimensional identification of microvascular pathology and neurovascular inflammation in severe white matter hyperintensity: a case report

 

All (normal-to-hyperintense)

NAWM

WMH

ρ (p value)

ρ (p value)

ρ (p value)

Vasculature (GLUT1)

 Vascular volume

0.116 (p < 0.001)

0.267 (p < 0.001)

 − 0.079 (p = 0.212)

 Network length

 − 0.240 (p < 0.001)

 − 0.010 (p = 0.798)

 − 0.272 (p < 0.001)

 Average branch length

0.443 (p < 0.001)

 − 0.002 (p = 0.970)

0.266 (p < 0.001)

 Density of vascular trees per mm3

 − 0.167 (p < 0.001)

0.009 (p = 0.818)

 − 0.017 (p = 0.787)

 Density of vascular branches per mm3

 − 0.375 (p < 0.001)

0.047 (p = 0.248)

 − 0.332 (p < 0.001)

 Branching per tree

 − 0.006 (p = 0.862)

 − 0.016 (p = 0.696)

 − 0.167 (p = 0.008)

 Vascular tortuosity index (≥ 1)

 − 0.020 (p = 0.563)

 − 0.239 (p < 0.001)

 − 0.015 (p = 0.819)

Microglia (IBA1)

 Microglia density per mm3

0.109 (p = 0.001)

 − 0.032 (p = 0.424)

 − 0.068 (p = 0.284)

 Scattered microglia volume

0.014 (p = 0.677)

 − 0.058 (p = 0.151)

 − 0.161 (p = 0.011)

 Clustered microglia volume

 − 0.069 (p = 0.043)

 − 0.129 (p = 0.001)

 − 0.252 (p < 0.001)

 Total microglia volume

 − 0.026 (p = 0.438)

 − 0.097 (p = 0.016)

 − 0.208 (p < 0.001)

Vascular inflammation (GLUT1 and IBA1)

 Vascular inflammation

 − 0.192 (p < 0.001)

 − 0.107 (p = 0.008)

 − 0.100 (p = 0.117)

  1. GLUT1 glucose transporter 1, IBA1 ionized calcium-binding adaptor molecule 1, IQR interquartile range (IQ25–IQ75), NAWM normal-appearing white matter, WMH white matter hyperintensity.
  2. Significant values are in bold.
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