Table 2 Transplantation details of patients with hepatitis‑associated aplastic anaemia (HAAA).

From: Exploring strategies to optimise outcomes in hepatitis-associated aplastic anaemia patients following haematopoietic stem cell transplantation

Characteristics

HAAA

n = 35

Interval from diagnosis to HSCT, days, median (range)

75 (34–412)

IST before HSCT

 ATG-based

2 (5.7%)

 CsA-based

22 (62.9%)

 No

11 (31.4%)

HCT-CI pre-HSCT

 0–1

32 (100.0%)a

 ≥ 2

0 (0.0%)a

Graft type

 PB only

29 (82.9%)

 PB + BM

5 (14.3%)

 BM only

1 (2.9%)

Blood type

 Match

24 (68.6%)

 Major mismatch

2 (5.7%)

 Minor mismatch

5 (14.3%)

 Mismatch

4 (11.4%)

Donor–patient sex match

 Female to female

6 (17.1%)

 Female to male

7 (20.0%)

 Male to male

16 (45.7%)

 Male to female

6 (17.1%)

HLA type

 5/10

10 (31.3%)a

 6/10

1 (3.1%)a

 7/10

3 (9.4%)a

 8/10

2 (6.3%)a

 9/10

0 (0.0%)a

 10/10

16 (50.0%)a

Conditioning regimen

 Bu + Cy + Flu + ATG

6 (17.1%)

 Cy + Flu + ATG

29 (82.9%)

GVHD prophylaxis

 CsA + MTX + MMF

12 (37.5%)

 FK506 + MTX + MMF

2 (6.3%)

 CsA + MTX

15 (46.9%)

 FK506 + MTX

3 (9.4%)

Cell compositions in allografts

 MNC, 108/kg

10.00 (8.02–11.90)

 CD34+ cells, 106/kg

2.92 (2.29–4.16)

 CD3+ T cells, 106/kg

169.17 (109.67–230.26)

 CD3+ CD4+ T cells, 106/kg

86.57 (56.60–123.30)

 CD3+ CD8+ T cells, 106/kg

64.94 (41.39–105.77)

 CD19+ B cells, 106/kg

38.52 (17.08–66.63)

  1. Categorical variables are presented as numbers (percentiles); continuous variables are presented as median (interquartile range) unless otherwise stated.
  2. ATG anti‐thymocyte globulin, BM bone marrow, Bu busulfan, CBC complete blood count, CsA cyclosporin, Cy cyclophosphamide, FK506 tacrolimus, Flu fludarabine, GVHD graft‐versus‐host disease, HAAA hepatitis‐associated aplastic anaemia, HCT‐CI haematopoietic cell transplantation specific comorbidity index, HID haploidentical donor, HLA human leukocyte antigen, IST immunosuppressive therapy, MMF mycophenolate mofetil, MNC mononuclear cells, MSD matched sibling donor, MTX methotrexate, MUD matched unrelated donor, PB peripheral blood.