Table 1 The known senolytic compounds Dasatinib (D), Quercetin (Q), the combination of both (D + Q), and Piperlongumine, and the targeted senescent cell types.

From: Computational identification of natural senotherapeutic compounds that mimic dasatinib based on gene expression data

Compound

Targeted senescent cell types

References

Piperlongumine

Human WI fibroblasts

29

Dasatinib (D)

Human and mouse preadipocytes

8

Quercetin (Q)

HUVECs

8

D + Q

Same cells as by D or Q

Primary mouse embryonic fibroblasts

Bone marrow-derived mesenchymal stem cell

Alveolar epithelial type II cells

senescent cells in skin ulcer samples

8,20,30,31,32