Table 3 Selected natural compounds mimicking the treatment with dasatinib.

From: Computational identification of natural senotherapeutic compounds that mimic dasatinib based on gene expression data

Rank

Dataset/ Score

Compound

Class of compound

Source

 

Dataset GSE39073—Kasumi-1 cells, reverse

   

1

0.0634

Piperlongumine

Amide alkaloid

Piper longum

20

0.0387

Parthenolide

Sesquiterpene lactone

Tanacetum parthenium

40

0.0352

Curcumin

Diarylheptanoid

Curcuma longa

 

Dataset GSE9633—prostatic cancer cell lines, reverse

   

27

0.071

Piperlongumine

Amide alkaloid

Piper longum

39

0.0656

Parthenolide

Sesquiterpene lactone

Tanacetum parthenium

 

Dataset PRJNA559155—breast cancer cells, mimic

   

7

0.0435

Phloretin (BRD-A36630025)

Dihydrochalcones

e.g. apples

32

0.0348

Parthenolide

Sesquiterpene lactone

Tanacetum parthenium

  1. These compounds were identified using the L1000CDS2 tool. The rank is based on the overlap; the overlap is a score based on the intersection length between input DEGs and the signature DEGs divided by the effective input, i.e. the intersection-length between input genes and L1000 genes. The full tables are provided as supplemental tables.
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