Figure 1
Curcumin and Curcuma longa L. extract regulate serum levels of AST and ALT and hepatic lipid accumulation in acute and chronic CCl4-models. Rats were intraperitoneally treated with CCl4 (0.1 mL/100 g, body weight) one time for (a) 1 day or (b) every other day for 4 weeks. Curcumin (200 mg/kg) or Curcuma longa L. extract (100, 200, or 300 mg/kg) was given each day for 3 days before CCl4 treatment and once daily after CCl4 treatment. Liver and blood samples were collected from all sacrificed animals. Six-h fasting serum levels of AST and ALT were determined. Six h fasting liver triglyceride, total cholesterol, and LDL-cholesterol levels were measured in the (c) 1 day and (d) 4 week CCl4-treated rats. (e) Representative images of liver sections from each group stained with hematoxylin–eosin and Oil-Red-O for lipid content. Scale bars = 50 µm. The experiments were repeated three times using tissues from at least three different rats. #P < 0.05, ###P < 0.001 vs. the control group; *P < 0.01 vs. the CCl4 group (n = 10 rats per group). Cur: curcumin, CL: Curcuma longa L., AST: aspartate aminotransferase, ALT: alanine aminotransferase.
