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SEM images (A: upper) show spherical and smooth surfaces of nanoparticles of Empty HA-ThCs and (B: upper) HA-coated 5-FU in ThCs-NPs at the scale of 5.0um while the TEM images (C) showed more precise image of HA-coated 5-FU in ThCs-NPs at scale of 50 nm24,35,38.