Table 2 Particle size significantly affected by the concentration of TCs and HA.

From: Enhancing therapeutic efficacy: sustained delivery of 5-fluorouracil (5-FU) via thiolated chitosan nanoparticles targeting CD44 in triple-negative breast cancer

Design summary

 

File Version

8.0.6.1

          

Study type

Response surface

Runs

12

        

Design type

Box–Behnken

Blocks

No blocks

        

Design mode

Quadratic

Build time

(r 0.75)

        

Factor

Name

Units

Type

Subtype

Minimum

Maximum

Coded

Values

Mean

SD

 

A

HA

mg

Numeric

Continuous

25.00

50.00

− 1.000 = 25.00

− 1.000 = 50.00

37.50

10.21

 

B

CHS

mg

Numeric

Continuous

20.00

100.00

− 1.000 = 20.00

− 1.000 = 100.00

60.00

32.66

 

C

FU

mg

Numeric

Continuous

0.10

1.00

− 1.000 = 0.10

− 1.000 = 1.00

0.55

0.37

 

Response

Name

Units

Obs

Analysis

Minimum

Maximum

Mean

SD

Ratio

Trans

Model

yi

Particle size

nm

12

Polynomial

390.12

3191

899.018

838.877

8.17953

None

Linear

Y2

PDI

 

12

Polynomial

0.162

1

0.6645

0.276644

6.17284

None

2FI

Y3

Zeta

+/−mV

12

Polynomial

− 27.6

38.9

4.19667

20.6281

N/A

None

2FI