Figure 1
From: Diving into the proteomic atlas of SARS-CoV-2 infected cells
SARS-CoV-2 infects cells from different tissues and elicits changes in protein abundance. (A) Cell lines from distinct tissues and biological systems were infected with SARS-CoV-2 in vitro and the infectomes (proteins differentially regulated due to viral response) were obtained by shotgun proteomics. (B) Total number of identified proteins (gray) and differentially regulated proteins (colored) in each cell type. (C) Proteins differentially regulated in the respective infectomes separated by direction of regulation. Bubble size indicates the number of differentially expressed proteins (DEPs). (D) Overview of SARS-CoV-2 infectome in all cell types (outer circle), showing proteins that are shared among groups as well as their respective regulation in the heatmap (inner circle). (E) Sankey plot of pathways enriched in at least 50% of infectomes.
