Figure 5 | Scientific Reports

Figure 5

From: Integrating X-ray phase-contrast imaging and histology for comparative evaluation of breast tissue malignancies in virtual histology analysis

Figure 5

A comparison of the visibility of the features of tumor cells of ILC. On the left side are images with pancytokeratin histological coloring and on the right side are images of PhC taken at 4 μm (b,d) and 1 μm (d) respectively. (b) Shows the full field-of-view \(\mu\)CT slice, while panel d is the enlargement of region inside the red dashed contour line. 1 μm \(\mu\)CT images (f) are able to perfectly identify the spaces occupied by tumor cells in the stroma. Scalebars corresponding, respectively, to 0.5 mm for (b) and (d), and 0.1 mm for (f). On the pancytokeratin images are visible tumor cells arranged in single files, cords, and single cells (red asterisk) surrounded by abundant dense extracellular matrix. In the 1 μm image (e) it can be seen the single collagen fibers surrounding the neoplastic epithelial elements.

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