Table 2 Results of Cox proportional hazard model for lipidome data.

From: Multiomics analysis to explore blood metabolite biomarkers in an Alzheimer’s Disease Neuroimaging Initiative cohort

Class

Rate of MCI patients (24 month)

Hazard ratio

P-value

LPC 18:1/0:0 ≤ − 0.112

74%

–

–

LPC 18:1/0:0 > − 0.112

55%

1.9

3.9e−8

GM3 d18:1/20:0 ≤ − 0.085

73%

–

–

GM3 d18:1/20:0 > − 0.085

56%

1.8

4.3e−7

PC 16:0_18:3-B ≤ − 0.172

69%

–

–

PC 16:0_18:3-B > − 0.172

60%

1.5

8.2e−04

LPE P-20:0/0:0 ≤ 0.194

68%

–

–

LPE P-20:0/0:0 > 0.194

59%

1.3

0.013

PC O-16:0/20:3 ≤ − 0.109

70%

–

–

PC O-16:0/20:3 > − 0.109

59%

1.4

0.022

  1. The rate of MCI patients indicates the rate of those who retained MCI status at 24 months from baseline. A hyphen (–) indicates control. P-values and hazard ratios were calculated compared to a control group. P-values were calculated using the Wald test.
Back to article page