Table 3 Results of Cox proportional model for metabolites and number of APOE4 alleles.

From: Multiomics analysis to explore blood metabolite biomarkers in an Alzheimer’s Disease Neuroimaging Initiative cohort

Class

Rate of MCI patients (24 month)

Hazard ratio

P-value

APOE4 = 0, ergothioneine > − 0.360

87%

–

–

APOE4 = 0, ergothioneine ≤ − 0.360

85%

1.1

0.77

APOE4 ≥ 1, ergothioneine > − 0.360

73%

2.4

0.0038

APOE4 ≥ 1, ergothioneine ≤ − 0.360

52%

4.7

3.7e−08

APOE4 = 0, GM3 d18:1/20:0 ≤ − 0.085

83%

–

–

APOE4 = 0, GM3 d18:1/20:0 > − 0.085

69%

1.9

0.001

APOE4 ≥ 1, GM3 d18:1/20:0 ≤ − 0.085

62%

2.7

7.5e-07

APOE4 ≥ 1, GM3 d18:1/20:0 > − 0.085

43%

4.6

2.3e-16

  1. The rate of MCI patients indicates the rate of those who retained MCI status at 24 months from baseline. A hyphen (–) indicates control. P-values and hazard ratios were calculated compared to a control group. P-values were calculated using the Wald test.
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