Figure 4
From: Overcoming radioresistance of breast cancer cells with MAP4K4 inhibitors
Targeting MAP4K4 suppressed DNA damage response and induced apoptosis in radioresistant cells. (A) Expressions of p-p38, p-H2AX, and RAD51 in SR cells treated with PF06260933 or GNE-495 for 24 h. p-p38, p-H2AX, and RAD51 levels are expressed as fold changes versus untreated cells (0 µM). (B) Expressions of apoptotic markers, cleaved caspase 3, and cleaved PARP, and survivin in SR cells treated with PF06260933 or GNE-495 for 24 h. Cleaved caspase 3, cleaved PARP, and survivin levels are expressed as fold changes versus untreated cells (0 µM). Results are presented as means ± SDs, and * and ** indicate p-values of < 0.05 and < 0.01 versus untreated cells, respectively.
