Figure 6
From: Overcoming radioresistance of breast cancer cells with MAP4K4 inhibitors
Targeting MAP4K4 overcame the radioresistances of SR and MR cells and suppressed their metastatic properties. (A) Radioresistance of SR and MR cells after exposure to 2 Gy/day for 5 days. SR and MR cells were highly resistant to 2 Gy/day × 5 radiation as compared with parental cells. Clonogenic survival assays of SR and MR cells exposed to 2 Gy/day for 5 days in presence or absence of (B) PF06260933 (PF) or (C) GNE-495 (GNE). Results are presented as means ± SDs, and * and ** indicate P values of < 0.05 and < 0.01, respectively. (D) Transwell invasion assays of SR and MR cells treated with 1 μM PF06260933 or 10 nM GNE-495 for 24 h.
