Figure 2

The cytotoxic effects of Y33 and pronase treated Y33 secretion (20 µg/mL) on oral cancer (KB and OSCC) and normal (fibroblast and HUVEK) cell lines after 24 h, 48 h and, 72 h incubation. Each bar represents the mean ± SE of six replicates. Error bares represent standard deviation of each mean. Asterisks denote statistically significant differences at < 0.05 level as compared with positive controls (doxorubicin and paclitaxel). Control: untreated cancer cell line. MRS: MRS treated cell lines. Dla: treated cells with in-market probiotic strain (Lactobacillus acidophilus PTCC 1643). Y33 + Pronase: pronase treated Y33 secretion. Dox: treated cells with doxorubicin anticancer drug. Pac: treated cells with paclitaxel anticancer drug.