Figure 3

Results from categorical linear model. (A) UpSet plot of number of peptides significantly and uniquely associated with each diagnostic contrast. Cognitive (Cog.) contrasts represent situations in which the two compared diagnostic classes have opposite levels of cognition. Pathology (Path.) contrasts represent situations in which the two compared diagnostic classes have opposite levels of neuropathology. (B) Volcano plot of frail vs control contrast, showing differentially enriched peptides between groups. Enriched peptides (up) are differentially increased in frail samples in comparison to control samples, and depleted peptides (down) are differentially decreased in frail samples in comparison to control samples. The most significantly associated proteoforms are labelled. ns = not significant. (C) Volcano plot of resilient vs dementia contrast, showing differentially enriched peptides between groups. Enriched peptides (up) are differentially increased in resilient samples in comparison to dementia samples, and depleted peptides (down) are differentially decreased in resilient samples in comparison to dementia samples. The most significantly associated proteoforms are labelled. (D) Boxplots showing examples of four proteoforms that are differentially enriched between frail and control samples. Significant adjusted p-values are labelled. (E) Boxplots showing examples of four proteoforms that are differentially enriched between resilient and dementia samples. Significant adjusted p-values are labelled.