Figure 4 | Scientific Reports

Figure 4

From: MiR-181a protects the heart against myocardial infarction by regulating mitochondrial fission via targeting programmed cell death protein 4

Figure 4

PDCD4 and BID participate in the regulation of apoptosis and mitochondrial fission in cardiomyocytes. (a) Expression of BID protein was detected using western blot. *P < 0.05. (b) Cell death in cardiomyocytes transfected as in (a) and then exposed to anoxia. *P < 0.05 compared with anoxia alone. (c) Mitochondrial fission in NRVCs transfected as in (a) and then exposed to anoxia. *P < 0.05 compared with anoxia alone. (d) INF/LV in hearts of mice infected with BID-siRNA or BID-sc at 24 h induced by myocardial infarct. n = 6 mice per group; *P < 0.05 compared with BID-sc. (e,f) Expression of BID protein was detected using western blot assay. *P < 0.05. (g,h) Representative images of subcellular localization of BID in NRVCs. Scale bar, 50 μm.

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