Table 3 Metabolites analyzed by MD in both hemispheres (A and B side) and in control side (C side) pre- and post-IHT.

Metabolite	Pathology	A side			B side			C side
Metabolite	Pathology	Pre IHT	Post IHT	p-value	Pre IHT	Post IHT	p-value	Pre IHT	Post IHT	p-value
Glucose (mmol/L) ± SD	TBI	1.888 ± 1.048	1.624 ± 0.9814	0.016	2.069 ± 0.9855	2.099 ± 1.427	0.225	3.71 ± 1.57	4.69 ± 4.23	0.8125
Glucose (mmol/L) ± SD	SAH	2.00 ± 0.90	1.80 ± 0.90	0.0084	1.89 ± 1.60	1.57 ± 1.03	0.035	2.38 ± 1.183	2.11 ± 1.88	0.126
Glycerol (Umol/L) ± SD	TBI	300.9 ± 380.2	376.0 ± 400.3	0.012	219.1 ± 266.7	244.8 ± 219.5	0.059	277.70 ± 136.70	296.60 ± 138.80	0.6194
Glycerol (Umol/L) ± SD	SAH	306.1 ± 282.8	351.70 ± 299.90	0.033	259.30 ± 190.10	289.30 ± 187.30	0.049	198.80 ± 73.57	195.40 ± 82.65	0.8192
Lactate (mmol/L) ± SD	TBI	3.470 ± 3.642	4.305 ± 3.904	0.001	2.366 ± 1.651	2.378 ± 1.109	0.059	1.55 ± 0.93	1.47 ± 0.94	0.6875
Lactate (mmol/L) ± SD	SAH	4.22 ± 2.70	4.851 ± 2.926	0.0008	4.46 ± 3.50	4.46 ± 3.06	0.1641	1.13 ± 0.80	1.11 ± 0.77	0.9393
Pyruvate (Umol/L) ± SD	TBI	116.8 ± 79.73	123.2 ± 81.02	0.185	92.25 ± 44.06	91.77 ± 31.08	0.255	78.23 ± 37.66	72.58 ± 46.87	0.7127
Pyruvate (Umol/L) ± SD	SAH	126.90 ± 63.46	138.00 ± 58.92	0.0029	121.20 ± 61.06	130.80 ± 61.47	0.0149	60.76 ± 34.03	53.50 ± 32.40	0.226
LPR ± SD	TBI	27.75 ± 12.94	35.73 ± 23.00	0.055	25.20 ± 9.927	27.83 ± 9.064	0.253	20.70 ± 10.19	21.47 ± 11.29	0.5781
LPR ± SD	SAH	32.78 ± 12.38	35.87 ± 17.52	0.229	34.90 ± 18.00	32.96 ± 14.68	0.446	21.47 ± 11.52	26.02 ± 19.90	0.2818

Mean concentration of each metabolite and SD from affected (A side) and non-affected (B side) hemispheres, and control side (C side) were shown. Patients were grouped according to the pathological diagnosis (SAH and TBI). The p-value was obtained by comparing the values pre- and post-IHT with the t test student.
SAH subarachnoid hemorrhage, TBI traumatic brain injury, IHT intrahospital transfer, LPR lactate/pyruvate ratio.
Significant values are in bold.

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