Table 2 Socio-demographic characteristics of the transplant cohort.

From: People with genetic kidney diseases on kidney replacement therapy have different clinical outcomes compared to people with other kidney diseases

Characteristics

Majority monogenic, N = 3466

Minority monogenic, N = 2855

Other, N = 15,539

P-value

Recipient age (years)

 < 0.001***

  < 20

208 (6.0)

560 (19.6)

886 (5.7)

 

 20–39

499 (14.4)

1153 (40.4)

4565 (29.4)

 

 40–59

2190 (63.2)

950 (33.3)

7477 (48.1)

 

 60–79

569 (16.4)

192 (6.7)

2610 (16.8)

 

 80 + 

0 (0.0)

0 (0.0)

1 (0.0)

 

Recipient gender

 < 0.001***

 Female

1510 (43.6)

1307 (45.8)

5396 (34.7)

 

 Male

1956 (56.4)

1548 (54.2)

10,143 (65.3)

 

Recipient smoking status

 < 0.001***

 Never

2062 (59.5)

1806 (63.3)

8539 (55.0)

 

 Former

1050 (30.3)

667 (23.4)

4902 (31.5)

 

 Current

254 (7.3)

303 (10.6)

1497 (9.6)

 

 Missing

100 (2.9)

79 (2.8)

601 (3.9)

 

Recipient BMI (kg/m2)

 < 0.001***

  < 18.5

187 (5.4)

364 (12.7)

824 (5.3)

 

 18.5–24.9

1355 (39.1)

1173 (41.1)

5736 (36.9)

 

 25–29.9

1121 (32.3)

706 (24.7)

4627 (29.8)

 

  > 30

600 (17.3)

425 (14.9)

3254 (20.9)

 

 Missing

203 (5.9)

187 (6.5)

1098 (7.1)

 

Recipient ethnicity

 < 0.001***

 White

3002 (86.6)

2254 (78.9)

10,779 (69.4)

 

 ATSI

20 (0.6)

68 (2.4)

646 (4.2)

 

 Maori

30 (0.9)

71 (2.5)

506 (3.3)

 

 Asian

158 (4.6)

177 (6.2)

1987 (12.8)

 

 Other

246 (7.1)

272 (9.5)

1474 (9.5)

 

 Missing

10 (0.3)

13 (0.5)

147(0.9)

 

Recipient comorbidities

 Peripheral vascular disease

46 (1.3)

29 (1.0)

822 (5.3)

 < 0.001***

 Coronary artery disease

223 (6.4)

106 (3.7)

1487 (9.6)

 < 0.001***

 Chronic lung disease

88 (2.5)

86 (3.0)

647 (4.2)

 < 0.001***

 Cerebrovascular disease

119 (3.4)

31 (1.1)

469 (3.0)

 < 0.001***

 Diabetes mellitus

111 (3.2)

107 (3.7)

4074 (26.2)

 < 0.001***

First KRT modality

 < 0.001***

 Haemodialysis

2025 (58.4)

1449 (50.8)

9338 (60.1)

 

 Peritoneal dialysis

918 (26.5)

916 (32.1)

4658 (30.0)

 

 Pre-emptive transplant

523 (15.1)

490 (17.2)

1543 (9.9)

 

Dialysis vintage (yr, mean, SD)

1.84 (2.44)

2.07 (2.91)

2.23 (2.68)

 < 0.001***

HLA mismatch (mean, SD)

3.29 (1.63)

3.09 (1.65)

3.33 (1.64)

 < 0.001***

Cold ischemia time (hr, mean, SD)

9.36 (6.31)

8.73 (6.65)

9.86 (6.46)

 < 0.001***

Donor age

 < 0.001***

  < 20

300 (8.7)

270 (9.5)

1603 (10.4)

 

 20–39

731 (21.1)

747 (26.2)

3989 (25.9)

 

 40–59

1750 (50.6)

1405 (49.3)

6849 (44.4)

 

 60 & above

678 (19.6)

427 (15.0)

2975 (19.3)

 

Donor source

 < 0.001***

 Deceased

2261 (65.2)

1665 (58.3)

10,848 (69.8)

 

 Live donor

1205 (34.8)

1190 (41.7)

4961 (30.2)

 

Transplant era

 < 0.001***

 1989–1998

540 (15.6)

607 (21.3)

2620 (16.9)

 

 1999–2008

1007 (29.1)

850 (29.8)

4462 (28.7)

 

 2009–2018

1607 (46.4)

1147 (40.2)

6876 (44.2)

 

 2018–2021

312 (9.0)

251 (8.8)

1581 (10.2)

 

Mortality rate

 1 year mortality

39 (1.1)

17 (0.6)

176 (1.1)

0.47

 3 year mortality

88 (2.5)

47 (1.6)

539 (3.5)

0.01**

 5 year mortality

144 (4.2)

81 (2.8)

961 (6.2)

 < 0.001***

Cause of mortalitya

 < 0.001***

 Cardiovascular

212 (24.3)

143 (26.5)

1382(31.5)

 

 Infection

137 (15.7)

91 (16.9)

723 (16.5)

 

 Withdrawal

79 (9.0)

60 (11.1)

416 (9.5)

 

 Cancer

242 (27.7)

101 (18.7)

840 (19.2)

 

 Other

191 (21.9)

141 (26.2)

993 (22.7)

 

 Missing

12 (1.4)

3 (0.6)

30(0.7)

 

Graft failure rate

 1 year graft failure

109 (20.1)

161 (19.5)

728 (21.8)

0.30

 3 year graft failure

162 (29.9)

250 (30.3)

1129 (66.2)

0.06

 5 year graft failure

217 (40.0)

343 (41.6)

1527 (45.7)

0.01**

Cause of graft failureb

 < 0.001***

 Rejection (acute + hyperacute)

46 (8.9)

56 (7.0)

243 (7.5)

 

 Chronic allograft nephropathy

297 (57.3)

464 (57.8)

1743 (53.5)

 

 Vascular

42 (8.1)

60 (7.5)

230 (7.1)

 

 Technical

14 (2.7)

18 (2.2)

73 (2.2)

 

 Glomerulonephritis

14 (2.7)

50 (6.2)

276 (8.5)

 

 Non-compliance

16 (3.1)

43 (5.4)

155 (4.8)

 

 Other

89 (17.2)

112 (13.9)

536 (16.5)

 

Disease in graft kidney

 < 0.001***

 BK virus nephropathy

74 (2.1)

55 (1.9)

390 (2.5)

 

 De novo glomerulonephritis

33 (1.0)

44 (1.5)

119 (0.8)

 

 Glomerulonephritis in graft

8 (0.2)

88 (3.1)

508 (3.3)

 

 Disease recurrence

4 (0.1)

5 (0.2)

85 (0.5)

 
  1. ATSI aboriginal and torres strait islander, BMI body mass index, HLA human leukocyte antigen, hr hour, kg kilogram, KRT kidney replacement therapy, m metre, SD standard deviation, yr year.
  2. Significance level: ** < 0.01, *** < 0.001.
  3. aPercentage expressed as proportion of people who died during follow-up.
  4. bPercentage expressed as proportion of people who had graft failure during follow-up.