Table 2 Socio-demographic characteristics of the transplant cohort.
Characteristics | Majority monogenic, N = 3466 | Minority monogenic, N = 2855 | Other, N = 15,539 | P-value |
---|---|---|---|---|
Recipient age (years) | < 0.001*** | |||
< 20 | 208 (6.0) | 560 (19.6) | 886 (5.7) | |
20–39 | 499 (14.4) | 1153 (40.4) | 4565 (29.4) | |
40–59 | 2190 (63.2) | 950 (33.3) | 7477 (48.1) | |
60–79 | 569 (16.4) | 192 (6.7) | 2610 (16.8) | |
80 + | 0 (0.0) | 0 (0.0) | 1 (0.0) | |
Recipient gender | < 0.001*** | |||
Female | 1510 (43.6) | 1307 (45.8) | 5396 (34.7) | |
Male | 1956 (56.4) | 1548 (54.2) | 10,143 (65.3) | |
Recipient smoking status | < 0.001*** | |||
Never | 2062 (59.5) | 1806 (63.3) | 8539 (55.0) | |
Former | 1050 (30.3) | 667 (23.4) | 4902 (31.5) | |
Current | 254 (7.3) | 303 (10.6) | 1497 (9.6) | |
Missing | 100 (2.9) | 79 (2.8) | 601 (3.9) | |
Recipient BMI (kg/m2) | < 0.001*** | |||
< 18.5 | 187 (5.4) | 364 (12.7) | 824 (5.3) | |
18.5–24.9 | 1355 (39.1) | 1173 (41.1) | 5736 (36.9) | |
25–29.9 | 1121 (32.3) | 706 (24.7) | 4627 (29.8) | |
> 30 | 600 (17.3) | 425 (14.9) | 3254 (20.9) | |
Missing | 203 (5.9) | 187 (6.5) | 1098 (7.1) | |
Recipient ethnicity | < 0.001*** | |||
White | 3002 (86.6) | 2254 (78.9) | 10,779 (69.4) | |
ATSI | 20 (0.6) | 68 (2.4) | 646 (4.2) | |
Maori | 30 (0.9) | 71 (2.5) | 506 (3.3) | |
Asian | 158 (4.6) | 177 (6.2) | 1987 (12.8) | |
Other | 246 (7.1) | 272 (9.5) | 1474 (9.5) | |
Missing | 10 (0.3) | 13 (0.5) | 147(0.9) | |
Recipient comorbidities | ||||
Peripheral vascular disease | 46 (1.3) | 29 (1.0) | 822 (5.3) | < 0.001*** |
Coronary artery disease | 223 (6.4) | 106 (3.7) | 1487 (9.6) | < 0.001*** |
Chronic lung disease | 88 (2.5) | 86 (3.0) | 647 (4.2) | < 0.001*** |
Cerebrovascular disease | 119 (3.4) | 31 (1.1) | 469 (3.0) | < 0.001*** |
Diabetes mellitus | 111 (3.2) | 107 (3.7) | 4074 (26.2) | < 0.001*** |
First KRT modality | < 0.001*** | |||
Haemodialysis | 2025 (58.4) | 1449 (50.8) | 9338 (60.1) | |
Peritoneal dialysis | 918 (26.5) | 916 (32.1) | 4658 (30.0) | |
Pre-emptive transplant | 523 (15.1) | 490 (17.2) | 1543 (9.9) | |
Dialysis vintage (yr, mean, SD) | 1.84 (2.44) | 2.07 (2.91) | 2.23 (2.68) | < 0.001*** |
HLA mismatch (mean, SD) | 3.29 (1.63) | 3.09 (1.65) | 3.33 (1.64) | < 0.001*** |
Cold ischemia time (hr, mean, SD) | 9.36 (6.31) | 8.73 (6.65) | 9.86 (6.46) | < 0.001*** |
Donor age | < 0.001*** | |||
< 20 | 300 (8.7) | 270 (9.5) | 1603 (10.4) | |
20–39 | 731 (21.1) | 747 (26.2) | 3989 (25.9) | |
40–59 | 1750 (50.6) | 1405 (49.3) | 6849 (44.4) | |
60 & above | 678 (19.6) | 427 (15.0) | 2975 (19.3) | |
Donor source | < 0.001*** | |||
Deceased | 2261 (65.2) | 1665 (58.3) | 10,848 (69.8) | |
Live donor | 1205 (34.8) | 1190 (41.7) | 4961 (30.2) | |
Transplant era | < 0.001*** | |||
1989–1998 | 540 (15.6) | 607 (21.3) | 2620 (16.9) | |
1999–2008 | 1007 (29.1) | 850 (29.8) | 4462 (28.7) | |
2009–2018 | 1607 (46.4) | 1147 (40.2) | 6876 (44.2) | |
2018–2021 | 312 (9.0) | 251 (8.8) | 1581 (10.2) | |
Mortality rate | ||||
1 year mortality | 39 (1.1) | 17 (0.6) | 176 (1.1) | 0.47 |
3 year mortality | 88 (2.5) | 47 (1.6) | 539 (3.5) | 0.01** |
5 year mortality | 144 (4.2) | 81 (2.8) | 961 (6.2) | < 0.001*** |
Cause of mortalitya | < 0.001*** | |||
Cardiovascular | 212 (24.3) | 143 (26.5) | 1382(31.5) | |
Infection | 137 (15.7) | 91 (16.9) | 723 (16.5) | |
Withdrawal | 79 (9.0) | 60 (11.1) | 416 (9.5) | |
Cancer | 242 (27.7) | 101 (18.7) | 840 (19.2) | |
Other | 191 (21.9) | 141 (26.2) | 993 (22.7) | |
Missing | 12 (1.4) | 3 (0.6) | 30(0.7) | |
Graft failure rate | ||||
1 year graft failure | 109 (20.1) | 161 (19.5) | 728 (21.8) | 0.30 |
3 year graft failure | 162 (29.9) | 250 (30.3) | 1129 (66.2) | 0.06 |
5 year graft failure | 217 (40.0) | 343 (41.6) | 1527 (45.7) | 0.01** |
Cause of graft failureb | < 0.001*** | |||
Rejection (acute + hyperacute) | 46 (8.9) | 56 (7.0) | 243 (7.5) | |
Chronic allograft nephropathy | 297 (57.3) | 464 (57.8) | 1743 (53.5) | |
Vascular | 42 (8.1) | 60 (7.5) | 230 (7.1) | |
Technical | 14 (2.7) | 18 (2.2) | 73 (2.2) | |
Glomerulonephritis | 14 (2.7) | 50 (6.2) | 276 (8.5) | |
Non-compliance | 16 (3.1) | 43 (5.4) | 155 (4.8) | |
Other | 89 (17.2) | 112 (13.9) | 536 (16.5) | |
Disease in graft kidney | < 0.001*** | |||
BK virus nephropathy | 74 (2.1) | 55 (1.9) | 390 (2.5) | |
De novo glomerulonephritis | 33 (1.0) | 44 (1.5) | 119 (0.8) | |
Glomerulonephritis in graft | 8 (0.2) | 88 (3.1) | 508 (3.3) | |
Disease recurrence | 4 (0.1) | 5 (0.2) | 85 (0.5) |