Table 4 Comparison of study parameters during acute COVID-19 infection stratified by disease severity (only significant differences and statistical trends shown).
Disease severity | ||||
|---|---|---|---|---|
Moderate (n = 3) | Severe (n = 11) | ICU (n = 20) | p-value* | |
Median (IQR) | Median (IQR) | Median (IQR) | ||
Neopterin [nmol/L] | 10.1 (7.7–18.3) | 42.5 (18.7–46.2) | 25.7 (21.2–45.7) | 0.051 |
Kyn [µmol/L] | 1.9 (1.5–1.9) | 3.7 (3.2–4.4) | 3.1 (2.5–3.9) | 0.017 |
Kyn/Trp [µmol/mmol] | 44.7 (27.7–57.3) | 78.8 (63.2–106.7) | 61.4 (50.6–89.6) | 0.063 |
Nitrite [µmol/L] | 13.8 (13.3–44.0) | 13.8 (8.2–22.9) | 33.2 (19.5–60.5) | 0.017 |
WBC [G/L] | 6.3 (4.3–6.7) | 5.2 (2.7–6.5) | 7.7 (5.3–10.0) | 0.032 |
Platelet count [G/L] | 295 (161–306) | 151 (112–218) | 250 (195–302) | 0.039 |
ANC [G/L] | 3.4 (2.1–4.3) | 3.1 (1.8–4.5) | 6.3 (4.2–8.4) | 0.004 |
Segmented neutrophils [%] | 54.3 (48.9–56.0) | 62.8 (55.4–66.0) | 81.6 (76.1–89.4) | 0.002 |
Monocytes [%] | 9.4 (7.3–14.1) | 9.0 (5.0–15.0) | 4.6 (2.8–7.4) | 0.037 |
Lymphocytes [% of WBC] | 35.5 (26.3–41.9) | 23.9 (16.5–27.9) | 11.2 (7.5–15.4) | 0.002 |
Lymphocytes [G/L] | 2.00 (1.80–2.24) | 0.95 (0.52–1.67) | 0.93 (0.72–1.06) | 0.023 |
Fibrinogen [mg/dL] | 453 (239–542) | 514 (361–592) | 597 (554–678) | 0.044 |
CRP [mg/dL] | 1.94 (0.06–2.09) | 3.50 (2.43–9.41) | 16.06 (8.05–22.09) | 0.003 |
PCT [µg/L] | 0.06 (0.06–0.06) | 0.08 (0.07–0.33) | 0.26 (0.13–0.75) | 0.012 |
IL-6 [ng/L] | 15.3 (2.3–41.4) | 41.6 (20.0–118.1) | 130.3 (37.3–313.2) | 0.028 |
Troponin T [ng/L] | 5.0 (5.0–8.2) | 15.5 (10.5–19.2) | 11.4 (7.8–15.5) | 0.020 |
NT-proBNP [ng/L] | 68 (66–77) | 443 (208–508) | 138 (82–464) | 0.044 |
Total serum iron [µmol/L] | 17.5 (4.6–19.4) | 4.8 (3.9–5.7) | 3.7 (2.3–4.4) | 0.011 |
