Figure 1
From: Differential prognostic values of the three AKT isoforms in acute myeloid leukemia
Expression of each AKT transcript in normal hematopoiesis. (A) Each dot in the curves shows micro-array normalized expression (log2) of each AKT transcript in cells sorted from individual healthy bone marrow donors of the BloodSpot #1 (top) or #2 (bottom) series of samples as described in the Method section. X axes: HSC = hematopoietic stem cell; HPC = hematopoietic progenitor cell; MPP = multipotent progenitor; CMP = common myeloid progenitor; GMP = granulocyte monocyte progenitor; PM = promyelocyte; MY = myelocyte; MM = metamyelocyte; BC = band cell; PMN = polymorphonuclear cell; Mono = monocyte. Array probes: 207163_s_at (AKT1), 225471_s_at (AKT2), 212609_s_at (AKT3) (top); 207163_s_at (AKT1), 225471_s_at (AKT2), 212607_at (AKT3) (bottom). Other probes gave similar tendencies. (B) Each dot shows RNA-seq normalized expression (log2 RPKM) of each AKT transcript in cells sorted from healthy donors of the Leucegene series as described in the Method section. X axis: CB CD34 + = cord blood CD34 + cells of individual donors; PB CD34 + = peripheral blood CD34 + cells pooled from 4 donors; Granulo = granulocytes; Mono = monocytes. (C) Each dot in the curves shows micro-array normalized expression of each AKT transcript in cells sorted from individual healthy bone marrow donors of the BloodSpot #3 series of samples as described in the Method section. X axis: HSC-1 = HSC CD133 + CD34dim; HSC-2 = HSC CD38- CD34 + ; MEP = megakaryocyte/erythrocyte progenitor; Mega-1 = CFU megakaryocyte; Mega-2 = megakaryocyte; Eryth-1 = eryth.CD34-CD71 + GlyA-; Eryth-2 = eryth.CD34-CD71 + GlyA + ; Eryth-3 = eryth.CD34-CD71loGlyA + ; Eryth-4 = eryth.CD34-CD71-GlyA + . Array probes: 207163_s_at (AKT1), 211453_s_at (AKT2), 212607_at (AKT3). Bars represent medians + /- 95% CI (confidence interval).
