Figure 4
From: Differential prognostic values of the three AKT isoforms in acute myeloid leukemia
Expression of each AKT transcript as a function of NPM1 and/or FLT3 mutational status. (A) Each dot shows expression (log2 RPKM) of each AKT as a function of NPM1 mutational status in samples of the IUCT-AML (top left, NPM1c = 14/40) or of the Beat-AML (bottom left, NPM1c = 125/445). Expression of each AKT in the Beat-AML cohort (n = 445) as a function of NPM1 expression in NPM1wt (n = 320) or NPM1c (n = 125) genotype, samples being ranked for each genotype in ascending order of global NPM1 expression (right). (B) Each dot shows expression of AKT3 in 445 samples of the Beat-AML cohort as a function of FLT3-ITD alone (n = 48), FLT3-TKD alone (n = 20), NPM1c alone (n = 58), NPM1c + FLT3-ITD (n = 51) or NPM1c + FLT3-TKD (n = 16) genotype. “wt” means no FLT3 or NPM1 mutation. (C) Expression of AKT3 in 445 samples of the Beat-AML cohort as a function of the PC2-34 score in NPM1wt (n = 320) or NPM1c (n = 125) genotype, samples being ranked for each genotype in ascending order of PC2-34 score. PRIM = primitive; MAT = mature. Bars represent medians with 95% CI. Trend curves are shown as dotted lines + coefficients of linear regression (r2).
