Table 2 Pharmacokinetic parameters of etomidate for the test and reference formulations after a single dose of etomidate through the intravenous infusion pump in healthy subjects (n = 51).

From: Pharmacokinetic and pharmacodynamic evaluation study of etomidate: a randomized, open-label, 2-period crossover study in healthy Chinese subjects

Pharmacokinetic parameters

Test

Reference

Tmax (min)

30.03 (10.2, 30.6)

25.18 (10.2, 30.2)

Cmax (ng/mL)

106.25 ± 32.890

106.29 ± 26.508

AUC0–t (min ng/mL)

7747.05 ± 1343.210

7735.67 ± 1037.371

AUC0–∞ (min ng/mL)

8282.72 ± 1369.054

8333.36 ± 1169.744

t1/2 (min)

591.10 ± 222.861

604.95 ± 231.461

  1. All values are expressed as mean ± SD except for Tmax values, which are expressed as median (range).
  2. AUC0–t area under the plasma concentration–time curve from time zero to the time of the last measurable concentration, AUC0–∞ area under the plasma concentration–time curve from time zero to infinity, Cmax maximum plasma drug concentration, Tmax time to reach Cmax, t1/2 half-time of terminal elimination.
Back to article page