Table 3 Bioequivalence assessment of pharmacokinetic parameters of etomidate for the test and reference formulations after a single dose of etomidate through the intravenous infusion pump in healthy subjects (n = 51).

From: Pharmacokinetic and pharmacodynamic evaluation study of etomidate: a randomized, open-label, 2-period crossover study in healthy Chinese subjects

Parameters

Ration of GLSM (%)

90% CI

CV (%)

Power (%)

Cmax (ng/mL)

97.91

91.33–104.96

21.17

99.9

AUC0–t (min ng/mL)

99.59

97.21–102.03

7.31

> 99.9

AUC0–∞ (min ng/mL)

99.74

97.22–102.33

7.72

> 99.9

  1. AUC0–t area under the plasma concentration–time curve from time zero to the time of the last measurable concentration, AUC0–∞ area under the plasma concentration–time curve from time zero to infinity, Cmax maximum plasma drug concentration, CV coefficients of variation, GLSM geometric least-squares mean.
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