Table 4 Pharmacodynamics parameters of etomidate for the test and reference formulations after a single dose of etomidate through the intravenous infusion pump in healthy subjects (n = 51).

From: Pharmacokinetic and pharmacodynamic evaluation study of etomidate: a randomized, open-label, 2-period crossover study in healthy Chinese subjects

Pharmacodynamics parameters

Test

Reference

t-BISmin (min)

22.0 (3.0, 59.0)

22.0 (1.0, 58.0)

BISmin

72.2 ± 16.57

69.5 ± 13.82

BISAUC0–60min

5396.94 ± 251.696

5383.30 ± 220.033

  1. All values are expressed as mean ± SD except for t-BISmin values, which are expressed as median (range).
  2. BISmin the minimal BIS value, BISAUC0–60 min the area under the BIS time curve from time 0 to 60 min after administration, t-BISmin the time to the minimal BIS value.
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