Table 5 Statistical bioequivalence assessment of pharmacodynamic parameters of etomidate for the test and reference formulations after a single dose of etomidate through the intravenous infusion pump in healthy subjects (n = 51).

From: Pharmacokinetic and pharmacodynamic evaluation study of etomidate: a randomized, open-label, 2-period crossover study in healthy Chinese subjects

Parameters

Ration of GLSM (%)

90% CI

CV (%)

Power (%)

BISmin

106.40

102.28–110.69

11.72

> 99.9

BISAUC0–60min

100.19

99.23–101.17

2.92

> 99.9

  1. BISmin the minimal BIS value, BISAUC0–60 min the area under the BIS time curve from time 0 to 60 min after administration, CV coefficients of variation, GLSM geometric least-squares mean.
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