Table 6 Modified MOAA/S scores of etomidate for the test and reference formulations after a single dose of etomidate through the intravenous infusion pump in healthy subjects (n = 51).

From: Pharmacokinetic and pharmacodynamic evaluation study of etomidate: a randomized, open-label, 2-period crossover study in healthy Chinese subjects

Scoring times

Grading

Result

Test

Reference

1

1, n (%)

51 (100%)

51 (100%)

2, n (%)

0

0

3, n (%)

0

0

4, n (%)

0

0

5, n (%)

0

0

2

1, n (%)

44 (86.3%)

45 (88.2%)

2, n (%)

7 (13.7%)

5 (9.8%)

3, n (%)

0

1 (2.0%)

4, n (%)

0

0

5, n (%)

0

0

3

1, n (%)

46 (90.2%)

41 (80.4%)

2, n (%)

5 (9.8%)

10 (19.6%)

3, n (%)

0

0

4, n (%)

0

0

5, n (%)

0

0

4

1, n (%)

51 (100%)

51 (100%)

2, n (%)

0

0

3, n (%)

0

0

4, n (%)

0

0

5, n (%)

0

0

5

1, n (%)

51 (100%)

51 (100%)

2, n (%)

0

0

3, n (%)

0

0

4, n (%)

0

0

5, n (%)

0

0

  1. Scoring criteria of modified MOAA/S scores:
  2. 1. Grade 1: alert, responds readily to name spoken in normal tone;
  3. 2. Grade 2: lethargic response to name spoken in normal tone;
  4. 3. Grade 3: no response to normal calls, but responds only after name is called loudly and/or repeatedly;
  5. 4. Grade 4: no response to loud and/or repeated calls, but responds only after mild prodding or shaking;
  6. 5. Grade 5: no response to mild prodding or shaking, but responds to noxious stimulation.
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