Figure 5 | Scientific Reports

Figure 5

From: Single-cell RNA sequencing unveils tumor heterogeneity and immune microenvironment between subungual and plantar melanoma

Figure 5

T/NK cells interact with melanocytes via the TIGIT-NECTIN2 axis. (A) Bar plot showing the number and strength of interactions between melanocytes and T/NK cells in PM1 and SM1. (B) Differences in interactions in the information flow of PM1 and SM1. (C) Dot plot showing receptor-ligand pair analysis of the interactions between melanocytes and T/NK cells. (D,E) Cell chat showing the interactions between TIGIT and its ligand in PM1 and SM1. The thickness of the lines represents strength. (F) Violin plots showing the expression intensity of TIGIT and its ligand NECTIN2/PVR in melanocytes subpopulations and T/NK cells subpopulations. (G,H) Pseudotime trajectory demonstrating the transcriptome lineage of 8T/NK cells subpopulations. Colors indicate pseudotime progression. (I) Line plot showing the development trend of module 4 in pseudotime trajectory. (J) The development trend of 4 modules of T/NK cells in pseudotime trajectory. (K) Immunofluorescence staining of TIGIT in PM and SM.

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