Figure 6 | Scientific Reports

Figure 6

From: Single-cell RNA sequencing unveils tumor heterogeneity and immune microenvironment between subungual and plantar melanoma

Figure 6

The expression of CD226-NECTIN2 axis in melanocytes and T/NK cells. (A,B) Cell chat showing the interactions between CD226 and its ligand in PM1 and SM1. The thickness of the lines represents strength. (C) Violin plots showing the expression intensity of CD226 and its ligand NECTIN2/PVR in melanocytes subpopulations and T/NK cells subpopulations. (D) Hematoxylin–eosin (HE) staining of PM and SM (× 100). Immunofluorescence staining of CD226 and NECTIN2 in PM and SM. Triple immunofluorescence staining of TIGIT, CD226, and NECTIN2. (E) SCENIC showing the main TFs of CD8+ Cytotoxic. (F) The interaction of TIGIT family receptors and ligands.

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