Figure 9
In vitro timeline kinetics of antigen-specific production of soluble mediators by PBMC from adults following 17DD-YF 1/5 fractional dose primary vaccination. Soluble mediators were measured in supernatants from in vitro PBMC cultures carried out before [NV(D0), n = 15] and 30–45 days after [PV(D30–45), n = 15] 17DD-YF 1/5 fractional dose primary vaccination. PBMC cultures were performed in the absence (unstimulated—Control Culture) and in the presence of 17DD-YF antigen (17DD-YF stimulated—17DD-YF Culture) and supernatants collected along the timeline kinetics (T0, T2, T4 and T6) for soluble mediators measurements by Luminex xMAP technology, as described in “Methods” section. The results are presented in line charts as median values of PV(D30–45)/NV(D0) ratio along the timeline kinetics. Color rectangles were used to underscore the soluble mediators with decreased (median < 1; 
) or increased (median > 1; 
) values.
