Table 2 Age- and sex-adjusted and multivariable-adjusted odds ratios for the presence of all-cause dementia and dementia subtypes according to serum high-sensitivity C-reactive protein level.

Serum hs-CRP, mg/L	No. of cases/participants	Age- and sex-adjusted		Multivariable-adjusted^a
Serum hs-CRP, mg/L	No. of cases/participants	OR (95%CI)	p	OR (95%CI)	p
All-cause dementia
< 1.0	367/7465	1.00 (reference)		1.00 (reference)
1.0–1.9	82/1379	1.08 (0.82–1.41)	0.60	1.04 (0.76–1.43)	0.80
2.0–2.9	38/442	1.57 (1.06–2.32)	0.03	1.68 (1.08–2.61)	0.02
≥ 3.0	86/799	1.70 (1.28–2.25)	< 0.001	1.51 (1.08–2.11)	0.02
P for trend		< 0.001		< 0.001
Alzheimer’s disease (isolated type)
< 1.0	269/7465	1.00 (reference)		1.00 (reference)
1.0–1.9	46/1379	0.77 (0.55–1.09)	0.14	0.72 (0.48–1.08)	0.11
2.0–2.9	25/442	1.33 (0.84–2.11)	0.23	1.76 (1.08–2.89)	0.02
≥ 3.0	58/799	1.47 (1.06–2.04)	0.02	1.61 (1.11–2.35)	0.01
P for trend		0.004		0.001
Non-Alzheimer’s dementia
< 1.0	75/7465	1.00 (reference)		1.00 (reference)
1.0–1.9	28/1379	1.84 (1.18–2.88)	0.007	2.02 (1.19–3.44)	0.009
2.0–2.9	7/442	1.32 (0.60–2.91)	0.50	0.64 (0.19–2.17)	0.48
≥ 3.0	20/799	1.80 (1.08–3.01)	0.03	1.06 (0.53–2.14)	0.87
P for trend		0.002		0.47

Mixed types including Alzheimer’s disease are not included in either Alzheimer’s disease (isolated) or non-Alzheimer’s dementia groups.
hs-CRP high-sensitivity C-reactive protein, OR odds ratio, CI confidence interval.
^aAdjusted for age, sex, low education, hypertension, ischemic heart disease, diabetes mellitus, serum total cholesterol, body mass index, chronic kidney disease, electrocardiogram abnormalities, history of stroke, smoking habit, alcohol intake, regular exercise, apolipoprotein E ε4 carrier status, depression, and research site.

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