Table 1 Clusters with Gene Ontology (GO) overrepresentations.
From: Network analysis of the proteome and peptidome sheds light on human milk as a biological system
Cluster | Gene Ontology domain\(^a\) | Gene Ontology annotation | Adjusted p value | Associated proteins |
|---|---|---|---|---|
1 | CC | Pentameric IgM immunoglobulin complex | \(1.60\times 10^{-2}\) | IGHM, IGJ |
4 | CC | Blood microparticle | \(1.18\times 10^{-7}\) | A1BG, CFH, C9, HPX, SERPINC1, AHSG, PLG, SERPINF2, ORM1, ORM2, HP, ALB, AFM, F2, CP, IGHG4, ITIH4 |
BP | Acute inflammatory response | \(2.62\times 10^{-6}\) | ORM2, HP, SERPINC1, SERPINA1, AHSG, F2, ITIH4, ORM1, SERPINF2 | |
6 | CC | Bounding membrane of organelle | \(6.40\times 10^{-6}\) | STOM, RAB1A, RHOA, SAR1A, SNAP23, PLIN3, RAB6A, CD36, RAP1B, CNP3, MGAT132, STX3, RAB18, EHD4, TLR2, GNB1, YKT6, ARF1, GLIPR2 |
MF | Hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | \(1.81\times 10^{-3}\) | RAP1B, ABCG2, RHOA, RAB18, RAB1A, ENTPD3, RALB, SAR1A, GNB1, ARF1, RAB6A | |
7 | CC | Extracellular space | \(7.52\times 10^{-3}\) | CD59, TIMP1, B4GALT14, LALBA, VTN, SERPING1, FAM3C, KLK6, TCN1, MIF, SPINT1, CSN2, GPX3, CSN3, DAG1, LGALS3BP, LTF, CA6, LRG1, VWA1, CD14, RNASET2 |
12 | CC | Fibrinogen complex | \(1.25\times 10^{-3}\) | FGA, FGB, FGG |
BP | Regulation of vasoconstriction | \(5.40\times 10^{-4}\) | FGA, FGB, FGG | |
13 | CC | High-density lipoprotein particle | \(2.42\times 10^{-9}\) | CLU, APOE, APOA1, APOA2, APOA4, APOB, PLTP |
MF | Intermembrane cholesterol transfer activity | \(1.07\times 10^{-8}\) | APOE, APOA1, APOA2, APOA4, APOB, PLTP | |
BP | Sterol transport | \(2.08\times 10^{-8}\) | CLU, APOE, APOA1, APOA2, APOA4, APOB, PLTP | |
14 | CC | Lysosome | \(1.57\times 10^{-6}\) | CTSB, NAGLU, LGMN, CTSD, FUCA1, ARSA, CTSZ, PSAP, HEXB, GRN |
BP | Granulocyte activation | \(1.31\times 10^{-2}\) | CTSB, PSMA5, 5, ,CTSD, CHI3L1, HSPA6, GNS, PDXK, CTSZ, PSAP, DPP7, FUCA1, ARSA, GRN, HEXB | |
23 | CC | Endoplasmic reticulum lumen | \(3.36\times 10^{-4}\) | B2M, HSPA5, HSP90B1, P4HB, PDIA3, RCN1, HYOU1, CALR, TGOLN2, CALU, SUMF2, SDC2 |
BP | Response to endoplasmic reticulum stress | \(1.24\times 10^{-3}\) | HSPA5, HSP90B1, P4HB, PDIA3, HYOU1, CALR, MAN1A1 | |
26 | CC | Microvillus | \(1.14\times 10^{-4}\) | RDX, MSN, EZR, SLC9A3R1 |
BP | Regulation of early endosome to late endosome transport | \(1.35\times 10^{-3}\) | RDX, MSN, EZR | |
59 | BP | ESCRT complex disassembly | \(3.96\times 10^{-2}\) | CHMP1B, CHMP2A, IST1 |
99 | MF | Transcription coactivator activity | \(2.58\times 10^{-2}\) | ACTN4, PARK7, ACTN1 |
110 | CC | Ribosomal subunit | \(1.32\times 10^{-3}\) | RPS16, RPS18, RPL3, RPS3A, RPS4X |
MF | Structural constituent of ribosome | \(1.89\times 10^{-3}\) | RPS16, RPS18, RPL3, RPS3A, RPS4X | |
BP | Establishment of protein localization to endoplasmic reticulum | \(1.40\times 10^{-3}\) | RPS16, RPS18, RPL3, RPS3A, RPS4X |
