Figure 2

Distinct transcriptomes of HCC and CHB patients compared to healthy transcriptomes. Volcano plots show the number of statistically (adjusted p value < 0.05, absolute log₂(fold change) ≥ 1) significant DEGs in PBMCs samples of (a) HCC and (b) CHB patients compared to Healthy controls. The volcano plots were created using R. Pearson correlation analysis along with the hierarchical clustering of (c) 107 DEGs in HCC vs. healthy and (d) 54 DEGs in CHB vs. healthy reveals within groups’ cohesion and altered gene expression profiles of PBMCs in HCC development. Red represents the positive correlation and blue represents the negative correlation.