Figure 4
From: Surfactant protein A promotes western diet-induced hepatic steatosis and fibrosis in mice
SPA deficiency attenuated western diet-induced liver inflammation. WT or SPA−/− mice were fed Chow or W-D for 8 weeks. The expression of pro-inflammatory genes in livers was detected by qRT-PCR, and the fold change of each mRNA level was normalized to the cyclophilin expression. (A) Chemokine (C–C motif) Ligand-2 (CCl2). (B) Tumor Necrotic Factor-α (TNF-α). (C) Interleukin-1 beta (IL-1β). (D) Nuclear Factor Kappa-B (NF-kB). (E) Vascular cell adhesion molecule-1 (VCAM-1) expression detected by Western blot. (F) Quantification of VCAM-1 protein expression shown in D by normalized to GAPDH.
