Figure 5
From: Surfactant protein A promotes western diet-induced hepatic steatosis and fibrosis in mice
SPA deficiency attenuated stellate cell activation and hepatic fibrosis in western-diet fed mice. (A) Immunostaining of actin alpha-2 (ACTA2) in the liver from WT or SPA−/− mice fed Chow or W-D for 8 weeks. (B) mRNA expression level of ACTA2 in the livers. (C) Picro Sirius Red staining for collagen deposition in liver tissues. Collagen deposit is indicated by the red stain. (D) Quantification of fibrotic area showing as the percentage of the total area in the tissue (n = 5). (E) Collagen type alpha 1 (Col1a1) mRNA levels. (F) transforming Growth factor-β1 (TGF-β1) mRNA levels.
