Table 4 Multivariable Cox regression analysis for associations to lower overall survival.

From: Oncological and functional outcome after laryngectomy for laryngeal and hypopharyngeal cancer: a population-based analysis in Germany from 2001 to 2020

Model 1: Effect of gender, TNM classification, and primary versus recurrent disease treatment

Parameter

HR

95%-CI

p

Gender

 Female

1

Reference

 Male

3.005

0.953–9.475

0.060

pT classification

 T2

1

Reference

 T3

1.555

0.807–2.995

0.187

 T4

1.947

1.029–3.686

0.041

pN classification

 N0

1

Reference

 N1

0.949

0.485–1.859

0.879

 N2

1.891

1.304–2.741

0.001

 N3

1.513

0.471–4.866

0.487

M classification

 M0

1

Reference

 M1

2.100

0.966–4.563

0.061

Laryngectomy for

 Primary treatment

1

Reference

 Tumor recurrence

1.711

1.167–2.508

0.006

Model 2: Effect of gender, UICC stage, and primary versus recurrent disease treatment

Gender

 Female

1

Reference

 Male

2.972

0.942–9.372

0.063

UICC staging

 Stage II

1

Reference

 Stage III

2.154

0.827–5.610

0.116

 Stage IV

3.455

1.395–8.556

0.007

Laryngectomy for

 Primary treatment

1

Reference

 Tumor recurrence

1.550

1.078–2.228

0.018

  1. Only significant parameters from the univariate analyses were included in the multivariate analyses. As the UICC stage was derived from the TNM classification, both parameters had to be analyzed in two different models.
  2. Significant values are in bold.
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