Table 1 Patient characteristics.

From: Gastrointestinal bleeding in elderly patients with atrial fibrillation: prespecified All Nippon Atrial Fibrillation in the Elderly (ANAFIE) Registry subgroup analysis

Characteristic

GI bleeding

Total n = 1139

Upper n = 339

Lower n = 760

Unspecified n = 74

None n = 31,136

p-value†

Age, years

82.1 ± 4.8

82.9 ± 4.8

81.7 ± 4.7

84.4 ± 5.3

81.4 ± 4.8

 < 0.001

Body mass index, kg/m2

23.6 ± 3.9

23.5 ± 4.1

23.8 ± 3.9

22.7 ± 3.6

23.3 ± 3.6

0.012

History of major bleeding

115 (10.1)

33 (9.7)

80 (10.5)

6 (8.1)

1324 (4.3)

 < 0.001

Use of anticoagulants

1080 (94.8)

322 (95.0)

720 (94.7)

71 (95.9)

28,750 (92.3)

0.002

 DOAC

763 (70.6)

222 (68.9)

519 (72.1)

49 (69.0)

20,822 (72.4)

0.200

  Standard dose

125 (19.0)

35 (17.9)

91 (20.5)

8 (19.0)

3701 (20.7)

0.419

  Over-dose

23 (3.5)

5 (2.6)

16 (3.6)

3 (7.1)

675 (3.8)

  Reduced dose

364 (55.4)

120 (61.2)

233 (52.5)

21 (50.0)

9184 (51.5)

  Under-dose

119 (18.1)

28 (14.3)

89 (20.0)

7 (16.7)

3511 (19.7)

  Off-label dose

26 (4.0)

8 (4.1)

15 (3.4)

3 (7.1)

769 (4.3)

 Warfarin

316 (29.3)

99 (30.7)

201 (27.9)

22 (31.0)

7917 (27.5)

0.214

Concomitant use of antiplatelet agents

230 (21.1)

70 (21.3)

153 (21.1)

14 (20.3)

5474 (18.5)

0.032

Concomitant use of PPIs

448 (41.1)

127 (38.7)

303 (41.8)

37 (53.6)

11,379 (38.5)

0.085

Concomitant use of P-glycoprotein inhibitor

33 (3.0)

10 (3.0)

21 (2.9)

2 (2.9)

528 (1.8)

0.003

Comorbidities

 Hypertension

904 (79.4)

273 (80.5)

600 (78.9)

57 (77.0)

23,408 (75.2)

0.001

 Diabetes mellitus

363 (31.9)

116 (34.2)

232 (30.5)

29 (39.2)

8370 (26.9)

 < 0.001

 Dyslipidaemia

500 (43.9)

149 (44.0)

337 (44.3)

30 (40.5)

13,228 (42.5)

0.343

 Hyperuricaemia

339 (29.8)

108 (31.9)

220 (28.9)

25 (33.8)

6975 (22.4)

 < 0.001

 Chronic kidney disease

304 (26.7)

100 (29.5)

195 (25.7)

16 (21.6)

6401 (20.6)

 < 0.001

 Severe hepatic dysfunction

14 (1.2)

4 (1.2)

10 (1.3)

0 (0.0)

281 (0.9)

0.255

 Myocardial infarction

92 (8.1)

27 (8.0)

60 (7.9)

10 (13.5)

1759 (5.6)

 < 0.001

 Heart failure

538 (47.2)

165 (48.7)

343 (45.1)

47 (63.5)

11,578 (37.2)

 < 0.001

 GI disease

453 (39.8)

128 (37.8)

316 (41.6)

31 (41.9)

9014 (29.0)

 < 0.001

Number of medications

7.7 ± 3.5

7.9 ± 3.5

7.6 ± 3.6

8.4 ± 4.1

6.6 ± 3.1

 < 0.001

  1. Data are n (%) or mean ± standard deviation. †Comparison of groups with (inclusive of patients with upper GI bleeding, lower GI bleeding, and unspecified site bleeding) and without GI bleeding.
  2. GI, gastrointestinal.
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